EIF2AK3 and neoplasm: To investigate the relationship between the effects of sorafenib on cell proliferation and basal pERK levels in HCC cell lines, here we evaluate the effects of sorafenib on four HCC tumor cell lines (SMMC-7721, MHCC97-L, MHCC97-H and HCCLM6) with different metastatic potentials and baseline pERK expression levels.