Remarkably, NPC patients have higher levels of both IgA and IgG classes in a large spectrum of EBV antigens including VCA gp125 and p18, EA-D, EBNA1 and gp78 compared with the healthy populations or populations with other EBV-associated diseases, indicative of a vigorous viral activity in NPC. The gene discussed is CD79A; the disease is nasopharyngeal carcinoma.