EFHD2 and cancer: There are at least five other examples of up-regulated spots that have previously been described as human epithelial cancer markers: ezrin (VIL2), a cytoskeletal protein linked to metastasis [37,38]; EF-hand domain containing protein-D2 (swiprosin-1), which regulates BCR apoptotic signaling [39]; α-enolase, a glycolytic enzyme that is elevated in cancer cells [40-43]; Elongation factor-1δ, a translation factor and proto-oncogene [44-46]; and Peroxiredoxin-3, which responds to elevated mitochondrial peroxide in cancer cells [47-51].