HLA-DRB1*08 was associated with a predisposition to LL leprosy (11.2% vs. 1.2%; P = 0.0037; OR = 12.00; CI = 1.51 – 95.12, pc = 0.0481), and HLA-DRB1*14 showed a tendency towards association with these patients (1.5% vs. 6.9%; P = 0.0595). This evidence concerns the gene HLA-DRB1 and leprosy.