Furthermore, comparison of network findings with other neurodegenerative diseases (e.g. Huntington's disease, PSP) and clinical/pathophysiological measures (e.g. (f)MRI, CSF, APOE status [38,39] or neuropsychological test-scores) would be of interest; it is conceivable that different cognitive symptoms arise from different types of network disturbance, or that neuronal or synaptic loss in discrete regions leads to specific network disturbance. The gene discussed is APOE; the disease is Huntington disease.