Roh et al. [51], retrospectively, studied T2 tongue cancer using monoclonal antibodies against HIF-1α, HIF-2α, CA-9, the glucose transporter (GLUT-1) and EPO receptors (EPORs), and found that only GLUT-1 was related to nodal stage and could, therefore, be used as a potential predictor of nodal metastates. This evidence concerns the gene SLC2A1 and tongue cancer.