ACE and kidney disorder: [22]. The repair of the glomerular function and the reversal of proteinuria can be due either to restructuring of existing and/or to de novo generation of podocytes. The first hypothesis, has been proposed for the reversal of glomerulosclerosis during ACE inhibition in the renal ablation model [23]. Alternatively, podocyte repopulation through remodelling of Bowman's capsule epithelial cells contributed to regression of renal disease in the Munich Wistar Frömter rat model of glomerular injury [24].