For example, in mice, the leukemia induced by NUP98-HOXA9 is preceded by a myeloproliferative phase whereas leukemia caused by overexpression of wild-type HOXA9 is not preceded by myeloproliferation [12]; and the in vitro effects of NUP98-HOXA9 on the differentiation and proliferation of mouse hematopoietic precursors are more profound than those of HOXA9 [13]. The gene discussed is NUP98; the disease is leukemia.