PFKM and cardiac hypertrophy: Two-month-old Pfkm−/− mice showed increased (about 55%) heart weight (Pfkm+/+, 4.4±0.1 mg/g b.w. vs. Pfkm−/−, 6.9±0.3 mg/g b.w.; (n = 5) p<0.01) and developed cardiac hypertrophy and evident cardiomegaly with age (Figure 5E and 5F).