In chronic ethanol-induced hepatotoxicity or CCl4-induced rat liver fibrosis, Panax notoginseng (Tianqi) extract or total saponin extracted from Panax notoginseng reduces the generation of MDA, scavenges free radicals, increases liver and serum SOD content and reduces the accumulation of body lipid peroxide [44-46]. Here, SOD1 is linked to Hepatic fibrosis.