The Cox regression model revealed that patients with a higher N stage, a higher M stage, and a higher density of IDO+cells in TDLN without tumor involvement had a shorter survival, whereas no relationship was observed between the survival and T stage as well as the levels of IDO and Bin1 in primary tumors, indicating that in this group of patients the density of IDO+cells in TDLN without tumor involvement were independently prognostic (Table 4). Here, IDO1 is linked to neoplasm.