When compared with a list of 258 genes upregulated by androgen in LNCaP cells (an immortal PCa cell line derived from a lymph node metastasis which has mutated AR) that was generated by DePrimo et al. [23], 69, 82, and 51 of these genes were also upregulated in E-CA-88 cells by clorgyline at 6, 24, and 96 hr, respectively, representing a highly significant enrichment by Chi-square test (Figure 4). Here, AR is linked to posterior cortical atrophy.