Of these factors, preoperative serum CEA level was the only significant prognostic factor for patients with stage II (Tables 6 and 7) and III (Tables 8 and 9) CRCs in both cancer-specific and overall survival categories (all P < 0.005), despite age was also one independent prognostic factor of overall survival in stage II and III CRC patients. This evidence concerns the gene CEACAM5 and colorectal carcinoma.