Notably, central nodes of proteins of the biological network, generated by the Pathway Architect assembly of GO designations for the most prominently over-represented genes, were shared in oral leukoplakia tissues and tumor tissues including S100 family (A7, 8, 9, 10, and 11), HSP family (HSPB1 and HSPA8), ANX family (A1, 3, 4, and 5), tumor metastasis suppressor NME2 and Rho GDP dissociation inhibitor alpha and beta (ARHGDIA and B), pyruvate kinase (PKM2), transgelin (TAGLN), glutathione S-transferase (GSTP1), SERPINA1, PCNA, and so on (Figure 6A). Here, PKM is linked to neoplasm.