CP and Alzheimer disease: The difficulties we experienced in detecting ceruloplasmin in 2D experiments with controls—in which we started from brain crude extracts—under the same conditions as in AD, suggest that the amount of ceruloplasmin in AD was higher than in control brains, in agreement with previous literature (Loeffler et al. 1996; Deibel et al. 1996; Castellani et al. 1999).