Several large epidemiologic studies have found that apolipoproteins, especially apoB or the ratio of apoB to apoA-I, are superior to classic lipid profile constituents (i.e. total, HDL and/or LDL cholesterol) in predicting coronary heart disease risk/myocardial infarction (Lamarche et al. 1996; St-Pierre et al. 2005; Walldius et al. 2001; Talmud et al. 2002; Meisinger et al. 2005; Jiang et al. 2004; Ridker et al. 2005; Shai et al. 2004; Moss et al. 1999; Yusuf et al. 2004) in the general population. The gene discussed is APOA1; the disease is coronary artery disorder.