NPPB and aortic stenosis: Since the clinical tools typically utilized to time the moment of intervention for valve repair or replacement are frequently limited to clinical judgment, an objective measure to guide the timing for intervention would be welcome, particularly since for instance recovery of LVEF or regression of LV mass is all but guaranteed after well-timed aortic valve replacement for aortic stenosis.55 Accordingly, the possible role of NT-proBNP in making the decision to operate upon these patients is of growing interest.