NPPB and hydrops fetalis: Nowadays, Brain Natriuretic Peptide (BNP) and its cleavage equivalent aminoterminal-proBNP (NT-proBNP) have proven its clinical diagnostic but also prognostic value in HF, and have shown to be superior as a diagnostic parameter for HF when compared to chest X-ray and parameters of physical examination.2–4 In this paper, we aim to discuss the background, the value, and of course the potential pitfalls encountered by clinicians using NT-proBNP testing in their daily clinical practice.