Specifically, in human models of ischemia, BNP levels have been shown to increase transiently both after exercise in patients with stable coronary disease and after uncomplicated coronary angioplasty, despite stable intracardiac filling pressures.22,23 Others have shown the rise in the level of BNP is correlated with the size of an ischemic territory during nuclear stress imaging.24 This evidence concerns the gene NPPB and ischemia.