Many studies have been shown that elevation of BNP as well as NT-proBNP levels obtained after the acute phase (median, 40 to 72 hours after symptoms onset) in patients with a broad range of ACS independently predicts mortality.17–19 However, in most of the reports, authors do not distinguish subjects with low ejection fraction and LV enlargement; in all studies, BNP levels appear related to increase of heart failure, predicting of cardiac remodeling and pump dysfunction. The gene discussed is NPPB; the disease is heart failure.