CRP and autoimmune disease: Of note, many of the autoantibodies commonly associated with SLE are directed against the major CRP ligands reported in the literature, namely, chromatin, histones, fibronectin, small nRNPs, and laminin (Du Clos et al. 1991; Black et al. 2004); this suggests for at least this autoimmune disease, a failure of the normal CRP clearance mechanisms.