Husain et al. (1998) demonstrated that acquisition of further resistance to cisplatin was associated with an increase in the expression of BRCA1 in MCF-7 cells. In a previous report on human ovarian cancer cells, up-regulation of BRCA1 was associated with more resistance to cisplatin, and the suppression of BRCA1 using its antisense oligonucleotide restored cisplatin sensitivity (Husain et al. 1998). Here, BRCA1 is linked to ovarian cancer.