The cancer candidates cover a >10-log concentration range with proteins such as immune modulating interleukins (1α andβ, 2, 5, 6, 9, 10, IFN-γ and GM-CSF) being present in normal plasma or serum in the pg/mL range while classical plasma proteins (albumin, transferrin, fibrinogen, and α-2-macroglobulin) are present at mg/mL levels. The gene discussed is IFNG; the disease is cancer.