In G6PD-deficient patients receiving CDA, 26/80 (33%) had such events (six cases of hemoglobin decreased, seven hematuria/hemoglobinuria [these were not always differentiated], two hemolysis, two hemolytic anemia and one blood methemoglobin) compared with 10/597 (2%) for G6PD normal (seven anemia, two hemoglobin decreased, one intravascular hemolysis) and 5/123 (4%) for female heterozygotes (two anemia, three hemoglobin decreased). Here, HBG2 is linked to anemia (phenotype).