MAPK8 and hepatocellular carcinoma: It should be noted that although both H-JNK1 and L-JNK1 HCCs samples showed decreased expression of IGFBP3 relative to the matched ANC samples as reported by others[20], the IGFBP3 level in L-JNK1 HCC tissue is much lower than that in H-JNK1 HCC tissue (Fig. 3B).