By re-analyzing and comparing our gene profiling data with the signature genes for HCC with a poor prognosis and hepatoblastoma (HB) reported recently[9,16], we found a striking overlap of the gene expression pattern in high JNK1 (H-JNK1) HCC tissue with the signature genes for HCC with a poor prognosis and HB, respectively. Here, MAPK8 is linked to hepatocellular carcinoma.