The top interactive networks for the down-regulated genes in the H-JNK1 HCC samples relative to the L-JNK1 HCC samples are those involved in hepatic transcription factor HNF4A network and metabolisms for lipids and drugs, such as the p450 family members (Figs. 5C and 5D; Additional file 8). Here, HNF4A is linked to hepatocellular carcinoma.