These overlapping HCC signature genes include S100P [12], S100A8 [22], S100A9 [12], CCL20 [11,25], PEG10 [16], CD24 [11,16,26], NTS [9], SPP1[24], PLAC8 [27], H19 [28,29], SPINK1 [30], GALNT7 [11] HMGA2 [16], C1orf106 [12], AMIGO2[11,23], AFP [11,22], UBE2C [11,31], SOX4[11,16,32], IER3 [9], TMED3 [12], IGFBP3 [33], S100A4 [34], and KRT19 [22] (Table 3). This evidence concerns the gene SPINK1 and hepatocellular carcinoma.