Furthermore, 12 up-regulated genes in H-JNK1 HCC samples were down-regulated in the L-JNK1 HCC samples (Fig. 2D and Additional file 6) and 10 down-regulated genes in the H-JNK1 HCC samples were up-regulated in the L-JNK1 HCC samples (Fig. 2D and Additional file 6). The gene discussed is MAPK8; the disease is hepatocellular carcinoma.