By comparing 25 benign nevi and 65 melanoma samples (41 primary and 24 metastases), we observed a statistically significant difference in Mcl-1 score between benign nevi and primary melanoma (P<0.0001) and between primary melanoma and metastatic disease (P = 0.04) (Figure 1A). The gene discussed is MCL1; the disease is metastatic neoplasm.