The function of LIMK1 in reorganization of the cytoskeleton has been studied extensively during developmental defects.4,5 Recently, a role of LIMK1 in progression and invasiveness of breast and prostate cancer has been predicted.6,7 In this paper, we explore the status of LIMK1 staining in the nucleus and cytoplasm as it relates to aggressiveness of prostate cancer. The gene discussed is LIMK1; the disease is Familial prostate cancer.