The function of LIMK1 in reorganization of the cytoskeleton has been studied extensively during developmental defects.4,5 Recently, a role of LIMK1 in progression and invasiveness of breast and prostate cancer has been predicted.6,7 In this paper, we explore the status of LIMK1 staining in the nucleus and cytoplasm as it relates to aggressiveness of prostate cancer. This evidence concerns the gene LIMK1 and prostate cancer.