As lentiviral Nor-1 over-expression additionally was shown to enhance adipocyte insulin signalling and glucose transporter-4 translocation [11] and siRNA knock-down showed that Nor-1 regulates gene expression for oxidative metabolism in skeletal muscle [12], we asked whether common genetic variation within the genetic locus harbouring the Nor-1 gene NR4A3 (OMIM ID 600542, Entrez Gene ID 8013) contributes to the development of prediabetic phenotypes, especially such as glucose intolerance and insulin resistance. The gene discussed is NR4A3; the disease is Insulin resistance.