NR4A3 and diabetes mellitus: As the METSIM study (diabetes prevalence: 13.8%) provides a power of 80% to detect a genotype relative risk of 1.15 assuming a SNP minor allele frequency of ~0.35 [see Additional file 3], we conclude that NR4A3 genetic variability may confer a rather modest effect on diabetes risk, and that analysis of this locus necessitates even larger replication samples.