We hypothesized that the relationship between inflammatory and hemostatic biomarkers including CRP, IL-6 plasma viscosity and several markers of activated coagulation, fibrinolysis and endothelial dysfunction [fibrinogen; coagulation factors VII, VIII, and IX; fibrin D-dimer, t-PA antigen, VWF activated partial thromboplastin time (APTT) and activated protein C (APC) ratio] differed between older men aged 60–79 years who develop (i) incident MI or CHD death and (ii) incident stable angina, uncomplicated by MI or CHD death. The gene discussed is VWF; the disease is angina pectoris.