In this prospective study of British men aged 60–79 years without baseline evidence of CHD, we have confirmed the results of previous studies [2–13] that circulating biomarkers of inflammation, endothelial dysfunction, coagulation and fibrinolysis (CRP, IL-6, fibrinogen, plasma viscosity, VWF and fibrin D-dimer) are associated with risk of incident major CHD events (MI or CHD death), after adjustment for traditional CHD risk factors. The gene discussed is IL6; the disease is coronary artery disorder.