However, in the recent report from the PRIME Study (a nested case–control prospective study of men aged 40–59 years), inflammatory markers were predictive of both acute coronary syndrome and stable angina but hemostatic markers in particular VWF plasma levels were higher in individuals who subsequently developed MI (fatal or non-fatal) but not in those who develop angina pectoris [11]. This evidence concerns the gene VWF and acute coronary syndrome.