Many prospective studies have shown independent associations between CHD events (MI and CHD death) and C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, von Willebrand factor (VWF), fibrin D-dimer and tissue plasminogen activator antigen (t-PA) in both middle-aged and older populations [2–13]. Here, VWF is linked to coronary artery disorder.