This is in keeping with the analysis by Morar et al., which showed a significant association between FLG genotype and eczema severity (P= 0·007 with the linear regression model).32 The only other reported analysis showed no significant association between the combined SPINK5, KLK7 and FLG null genotype although the numbers were small (n= 99).33 However, the finding of a statistically significant association does not necessarily imply a clinically significant association. The gene discussed is SPINK5; the disease is Eczematoid dermatitis.