Keratosis pilaris and palmar hyperlinearity are each independently associated with FLG null mutations in this cohort.17 The association may be coincidental, as keratosis pilaris and hyperlinear palms are both features of ichthyosis vulgaris,34,35 but this is unlikely as the statistical association persists after excluding the ichthyosis vulgaris cases. This evidence concerns the gene FLG and ichthyosis vulgaris.