Additional candidate gene categories chosen, included autophagy (BECN1 (GeneID: 8678), FRAP1 (GeneID: 2475)), tumor suppression (TP53 (GeneID: 7157), CDKN2A (GeneID: 1029), ING1 (GeneID: 601566)), DNA methylation (TRDMT1 (GeneID: 1787), DNMT3A (GeneID: 1788), DNMT3B (GeneID: 1789)), stem cell activation (NOTCH1 (GeneID: 4851), DLL1 (GeneID: 28514)), and Progeria syndromes (LMNA (GeneID: 4000), ZMPSTE24 (GeneID: 10269), KL (GeneID: 9365)). This evidence concerns the gene DNMT3A and neoplasm.