When we adjusted tumor-free survival (Fig. 3B) to the time of tamoxifen injection, it was clear that later excision of p53 (6 and 12 months) resulted in a reduced median tumor latency relative to excision of p53 at 3 months (p3:6 = 0.005, p3:12 = 0.014, p6:12 = 0.389). The gene discussed is TP53; the disease is neoplasm.