Experiments with large weights include expected conditions such as exercise (GSE1659), Alzheimer's disease (GSE5281) and Pgc1α over-expression (GSE4330) as well as lesser-studied contexts including down-regulation of OxPhos followed by recovery during time-courses of skeletal muscle regeneration (GSE469, GSE5413). This evidence concerns the gene PPARGC1A and early-onset autosomal dominant Alzheimer disease.