Numerous transgenic and knockout mouse models of RP have been developed, in which a mutation or knockout of a photoreceptor or RPE specific gene results is an approximation of the human clinical phenotype, often exhibiting an abbreviated time course; among these are Rho [40], Pde6b [41], RDS [42], Rom1 [43], Crx [44], Tub [45], Gucy2e [46], RPE65 [47], and others. This evidence concerns the gene GUCY2EP and retinitis pigmentosa 1.