TJP1 and malaria: Gillrie et al. showed that parasite sonicates but not intact malaria-infected red blood cells disrupt the endothelial (dermal and pulmonary, not brain) barrier, revealed by discontinuous immunofluorescent staining of endothelial junction proteins, formation of interendothelial gaps in monolayers, and loss in total protein content of claudin 5 and redistribution of ZO-1 [44].