Recently, a combined sequencing and haplotype mapping study found that within the 298 kb homologous region between the two proposed risk haplotypes, only HLA-C encoded variants unique to these haplotypes at the level of translated protein, which at the same time conferred increased risk of psoriasis, strongly suggesting that HLA-C is the Ps susceptibility gene, and excluded the telomeric region [12]. This evidence concerns the gene HLA-C and psoriasis.