Correction of RasGRF1 expression for the number of RasGRF1-positive cells confirmed that RasGRF1 expression was enhanced in both the synovial sublining (P < 0.005) and the intimal lining layer (P < 0.05) of RA patients compared with non-RA patients (data not shown). The gene discussed is RASGRF1; the disease is rheumatoid arthritis.