Because abnormalities of chromosome 7 have been associated with colorectal carcinoma, we also hypothesised that loss of alleles might lead to underexpression of SLC26A3. However, no loss of SLC26A3 was detected using the real-time PCR methodology, showing that some other mechanism must be involved in downregulation of the SLC26A3 gene. The gene discussed is SLC26A3; the disease is colorectal carcinoma.