In the recent years there is more widespread support for using a lower PSA threshold in the young population; recent investigations note that biopsy in men with PSA between 2.6 and 4.0 ng/ml may detect clinically significant prostate cancers at an organ-confined stage.[11] The age-specific and PSAD ranges in our study [Table 3] give a suggestion as when to evaluate a subject for malignancy. The gene discussed is KLK3; the disease is prostate cancer.