Akt1 correlated with high prostate specific antigen (PSA) whereas Akt3 correlated with invasion, metastases and hormone refractory disease.[64] PTEN is a phosphatase that opposes the function to PI3K, dephosphorylating PIP3 and deactivating Akt, thus operating as a tumor suppressor. Here, KLK3 is linked to neoplasm.