Loss of PTEN has been shown to correlate with tumor recurrence and progression to androgen independence.[65] In a model using PTEN ± mice, usually susceptible to the development of multiple tumors, the inhibition of Akt reduced the onset of malignancy, most significantly in prostate cancer reinforcing the role of Akt in prostate carcinogenesis.[66]. Here, AKT1 is linked to Familial prostate cancer.