While the member miRNAs were significantly downregulated in LNCaP, PC-3 and DU 145 cells as compared to their expression in MDA PCa 2b cells (Figure 5A), the MCM7 mRNA was significantly upregulated in DU 145 cells (p < 0.01, table 4) and PC-3 cells (p < 0.0001, table 4), and was expressed at similar level in LNCaP cells as compared to the expression in MDA PCa 2b cells (Figure 5B). Here, MCM7 is linked to posterior cortical atrophy.