Effects on apoptosis in MM cells is secondary to increased potentiation of TNF related Apoptosis inducing ligand (TRAIL), inhibition of apoptosis protein-2, increased sensitivity to Fas mediated cell death, and up regulation of caspase-8 activation, down regulation of caspase-8 inhibitors (FLIP, cIAP2), down regulation of NF-κb activity and inhibition of prosurvival effects of IGF-1[36]. Here, CASP8 is linked to Miyoshi myopathy.