TP53 and myeloid leukemia: Prototypic T-, B- and myelogenous leukaemia cell lines as well as fresh AML blasts were all susceptible to DRB-induced cell death, suggesting that the transcription stress response imposed by DRB is very powerful in inducing apoptosis independently of a cell's p53 status and without inducing DNA damage, thus providing an attractive approach to the treatment of some forms of cancer.