ESR1 and hepatocellular carcinoma: The bisphenolic metabolite of methoxychlor, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), for example, has been shown to act as an ERα agonist and ERβ antagonist in human hepatoma (HepG2) cells (Gaido et al. 2000).