DICER1 and cancer: The Dicer protein is a part of the RISC loading, small RNA processing complex, including its co-factor TRBP (TAR RNA binding protein), PACT, and Ago2, which could affect its stability depending on their respective expression in cancer cells (Chiosea et al, 2006, 2007; Lee et al, 2006; Zhang et al, 2006; Blenkiron et al, 2007).