We assessed whether Dicer expression could be regulated transcriptionally and post-transcriptionally in the human cancer progression model developed by Elenbaas et al (2001) consisting of normal HMECs, HMECs+hTERT (telomerase catalytic subunit), HMECs+LT (SV40 large-T antigen)+hTERT, and HMLER (HMECs+LT+hTERT+H-rasV12). This evidence concerns the gene LTA and cancer.