Thus it has been shown that the downstream signalling component of EGFR, phosphorylated AKT, had a significantly higher expression in radioresistant cases compared with cancer tissue obtained from a radiosensitive group of cervical cancer patients in whom radiosensitivity was defined as no local recurrence at least 3 years after treatment (Kim et al, 2006). The gene discussed is AKT1; the disease is cervical cancer.