Two (miR-126 and miR-126*), three (miR-224, miR-368 and miR-382) and seven miRNAs (from the polycistronic miR17-92 cluster) are sufficient to predict CBF AML, t(15;17) and MLL AML respectively, resulting in a diagnosis accuracy better than 94% (Table 1). The gene discussed is KMT2A; the disease is acute myeloid leukemia.