Our group recently reported that over-expressing miR-29b in AML cell lines and primary AML blasts down-regulates the expression of DNA methyltransferases; DNMT1, DNMT3A and 3B. MiR-29b targets directly DNMT3A and 3B and indirectly DNMT1 through its activator Sp1. Here, SP1 is linked to acute myeloid leukemia.