NPM1 and cyclic hematopoiesis: Interestingly, miR-10a, 10b and miR-196b have recently been linked to molecular or chromosomal alterations in subtypes of AML, in particular CN-AML with mutated NPM1. Garzon et al (2008b) identified a statistically significant up-regulation miR-10a, miR-10b in CN-AML with NPM1 mutation.