In terms of SR-B1 cell surface expression, only the Huh7-6 cell line had undetectable levels of this critical HCV entry factor (Figure S2C); however, complementation of Huh7-6 cells with exogenous SR-B1 expression alone did not restore its permissiveness for HCVpp (Figure 6C) or HCVcc (data not shown) infection, suggesting that although Huh7-6 cells lacked detectable cell surface expression of SR-B1, this receptor alone was not the limiting factor precluding HCVpp entry. Here, SCARB1 is linked to infection.