IGF1 and Duchenne muscular dystrophy: These findings have led to studies examining the molecular effects of IGF-1 treatment, including potential protective and regenerative effects of exogenous IGF-1 in a variety of animal models of degenerative musculoskeletal diseases and defects, including Duchenne's muscular dystrophy and age-related muscle degeneration, cancer models, and lymphocyte activation [5-8].