The IHC study reported here showed its expression was up-regulated in the carcinoma tissues of liver, colon, esophagus, lung and breast carcinomas compared with their corresponding normal tissues, and the positive ratios of APMCF1 in liver, colon, esophagus, lung and breast carcinomas with a large samples were 96%, 80%, 57%, 58% and 34% respectively. The gene discussed is SRPRB; the disease is carcinoma.