Such as the MAL protein, a component of the protein machinery for apical transport in epithelial polarized cells and a component of membrane rafts which are micro-domains that play a central role in signal transduction acting as a scaffold in which molecules of signal transduction pathways can interact [24,25], has been shown expressed in ovarian cancers, most notably clear cell and serous cancers [26]. The gene discussed is MAL; the disease is ovarian cancer.