Moreover, experiments carried out on monocytes and macrophages derived from rheumatoid arthritis demonstrated that the role of CD147 in MMP production and cell invasion enhanced MMP-9 production through extracellular signal-related kinase 1/2 (Erk1/2) and JNK, whereas MMP-2 production was not modulated at all. Here, MMP2 is linked to rheumatoid arthritis.