In contrast, expression of CCR4 and CCR3 (Th2-type receptors) on CD4+ T cells is significantly decreased in the blood of MS patients at the time of relapse compared to healthy controls, and CCR4 expression is significantly decreased in CSF CD4+ T cells compared to peripheral blood CD4+ T cells [Misu et al. 2001]. The gene discussed is CD4; the disease is myeloid sarcoma.